Regulation of gene expression by growth hormone
نویسندگان
چکیده
منابع مشابه
Regulation of growth hormone-releasing hormone gene expression and biosynthesis.
Growth hormone-releasing hormone (GRH) was initially isolated, characterized, sequenced, and cloned from human tumors and subsequently from the hypothalamus of humans and other animal species. Extensive structure-function studies have indicated the amino terminus to be most important for its biologic action, and the primary mechanism of its bioinactivation occurs by cleavage of an amino termina...
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The thyroid hormones (3,5,3',5'-tetraiodo-L-thyronine [L-T4]' and 3,5,3'triiodo-L-thyronine [L-T3]) have marked effects on the growth, development, and metabolic function of virtually all organ systems and tissues ofhuman beings and other higher organisms (1-3). L-T4 was one of the first hormones to be isolated and its structure determined (4-6). Several decades later L-T3 was identified in the...
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Recombinant clones containing exon 3 of the insulin-like growth factor I (IGF-I) gene were isolated from a mouse genomic library. These sequences were used to generate an RNA probe, which was used in a solution hybridization assay to quantitate IGF-I mRNA in various murine tissues as a function of growth hormone status. The liver is the major site of IGF-I synthesis and the level of IGF-I mRNA ...
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The mRNA expression of growth hormone (GH) gene in early development stages of Siberian sturgeon was investigated using RT-PCR method. Samples were collected from unfertilized eggs up to 50 days post hatched (dph) larvae in 11 different times. Ribosomal protein L6 (RPL6) transcripts were used as the internal standard during quantification of GH mRNA expression. The results showed that the GH mR...
متن کاملCREB-independent regulation by CBP is a novel mechanism of human growth hormone gene expression.
Hypothalamic growth hormone-releasing hormone (GHRH) stimulates growth hormone (GH) gene expression in anterior pituitary somatotrophs by binding to the GHRH receptor, a G-protein-coupled transmembrane receptor, and by mediating a cAMP-mediated protein kinase A (PKA) signal-transduction pathway. Two nonclassical cAMP-response element motifs (CGTCA) are located at nucleotides -187/-183 (distal c...
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ژورنال
عنوان ژورنال: Molecular and Cellular Endocrinology
سال: 2020
ISSN: 0303-7207
DOI: 10.1016/j.mce.2020.110788